Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

Hallo

Hab eine neue Haarwuchsstudie entdeckt!

So wie ich das verstanden habe,kann Himbeerextrakt IGF1 anregen, und Haut und Haarwuchs verbessern?


Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N.
Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

Sensory neurons release calcitonin gene-related peptide (CGRP) on activation. We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans. Raspberry ketone (RK), a major aromatic compound contained in red raspberries (Rubus idaeus), has a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1muM, significantly increased CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation. Topical application of 0.01% RK increased dermal IGF-I levels at 30min after application in WT mice, but not in CGRP-knockout mice. Topical application of 0.01% RK increased immunohistochemical expression of IGF-I at dermal papillae in hair follicles and promoted hair re-growth in WT mice at 4 weeks after the application. When applied topically to the scalp and facial skin, 0.01% RK promoted hair growth in 50.0% of humans with alopecia (n=10) at 5 months after application and increased cheek skin elasticity at 2 weeks after application in 5 females (p<0.04). These observations strongly suggest that RK might increase dermal IGF-I production through sensory neuron activation, thereby promoting hair growth and increasing skin elasticity.

http://www.ncbi.nlm.nih.gov/pubmed/18321745?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum


Gruss Flöte

Hallo Flötenspiel


Sehr interessanter Fund.....gute Arbeit!Ganz neue Studie....sozusagen frisch vom Fass.....

Das zeigt mal wieder das einmal die Natur für vieles einen passenden Deckel hat.Und es bestätigt wieder einmal wie wichtig doch das IGF-1 für Haut und Haarwuchs ist.


Ja....es handelt sich hier um einen Auszug aus der roten Himbeere.Und zwar um Himbeer-Keton.Seine Strucktur ähnelt dem Capsaicin,welches in anderen Studien topisch wie auch oral,günstige Einflüsse auf Hautqualität und Haarwuchs bei AGA gezeigt hat.Der Himbeer-Keton hat hier bei Mäusen Haarwuchs induziert,und ebenso im Rahmen dieser Untersuchung topisch aufgetragen bei Menschen mit AGA,den Haarwuchs über IGF-1 Erhöhung im Haarfollikel,nach bereits 5 Monaten verbessert.Weiter hat es hier u.a auch bei Frauen topisch aufgetragen die Hautqualität verbessert.


Mal schauen ob das was für euch ist,bzw ob der Auszug erschwinglich und in Eigenproduktion Herstellbar für Betroffene ist.


Viele Grüsse

Tino